Important Safety Information Including Boxed Warning and Indication

Most Important Information you should know about Osphena®

Osphena® works like estrogen in the lining of the uterus, but can work differently in other parts of the body. Taking estrogen alone or Osphena® may increase your chance for getting cancer of the lining of the uterus. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause, so tell him or her right away if this happens while you are using Osphena®.

Osphena® may increase your chances of having a stroke or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena®.

Call your healthcare provider right away if you have changes in vision or speech, sudden new severe headaches, and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue. Osphena® should not be used if you have unusual vaginal bleeding, have or have had certain types of cancers (including cancer of the breast or uterus), have or have had blood clots, have had a stroke or heart attack, have severe liver problems, are allergic to Osphena® or any of its ingredients, or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.

Possible side effects of Osphena®

Serious but less common side effects can include stroke, blood clots and cancer of the lining of the uterus.

Common side effects may include hot flashes, vaginal discharge, muscle spasms and increased sweating.

Tell your healthcare provider about all of the medicines and supplements you take, as some medicines may affect how Osphena® works. Osphena® may also affect how other medicines work.

Duchesnay USA encourages you to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Indication: What is Osphena®?

Osphena® is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Please read accompanying Patient Information for Osphena®(ospemifene) tablets, including Boxed Warning in the U.S. Full Prescribing Information.

For U.S. Residents Only

Let’s Talk About Sexual Intimacy After Menopause

Sex

Why sex hurts

What causes painful sex after menopause

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How Osphena® helps

Osphena®, the only once-daily oral, hormone-free tablet, can treat moderate to severe painful sex in as little as 12 weeks

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Dr. Lisa Masterson TALKS About Sexual Intimacy

Take this quiz to find out if you should talk to your healthcare provider about your moderate to severe painful sex due to menopause.

Hear what Dr. Lisa Masterson has to say about sexual intimacy after menopause and why it is healthy and important.

PAINFUL INTERCOURSE

The menopause symptom no one talks about.

LEARN WHAT’S CAUSING YOUR PAIN

ORAL, HORMONE FREE

Find out how ORAL, HORMONE-FREE Osphena® can help.

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OSPHENA® AT HOME

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