Important Safety Information Including Boxed Warning and Indication


Osphena® works like estrogen in the lining of the uterus (endometrium), but can work differently in other parts of the body. Taking estrogen alone or Osphena® may increase your chance for getting cancer of the lining of the uterus. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause, so tell him or her right away if this happens while you are using Osphena®.

Osphena® may increase your chances of having a stroke or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena®.

Indication: What is Osphena®?

Osphena® is a prescription oral pill that treats:

  • moderate to severe painful intercourse,
  • moderate to severe vaginal dryness, symptoms of changes in and around your vagina, due to menopause.

Most Important Information you should know about Osphena®

Call your healthcare provider right away if you have unusual vaginal bleeding, changes in vision or speech, sudden new severe headaches, and pains in your chest or legs with or without shortness of breath, weakness and fatigue.

Who should not take OSPHENA?

Osphena® should not be used if you have unusual vaginal bleeding, have or have had certain types of cancers (including cancer of the breast or uterus), have or have had blood clots, had a stroke or heart attack, have severe liver problems, are allergic to Osphena® or any of its ingredients, or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.


Serious but less common side effects can include:

  • stroke
  • blood clots
  • cancer of the lining of the uterus

Less serious, but common side effects include:

  • hot flushes or flashes
  • vaginal discharge
  • muscle spasms
  • headache
  • excessive sweating (hyperhidrosis)
  • heavy vaginal bleeding (vaginal hemorrhage)
  • night sweats

Tell your healthcare provider about all of the medicines and supplements you take, as some medicines may affect how Osphena® works. Osphena® may also affect how other medicines work.

Duchesnay USA encourages you to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please read accompanying Patient Information for Osphena®(ospemifene) tablets, including Boxed Warning in the U.S. Full Prescribing Information.

Osphena® now also indicated for moderate to severe vaginal dryness, a symptom of changes in and around your vagina due to menopause
How Osphena® Helps

Osphena is the only oral, hormone-free treatment for moderate to severe painful sex due to menopause

Find answers to your questions about Osphena® here!


How can I save on my Osphena® prescription?
Please visit our savings section for details.
Does the Osphena Savings Card need to be activated before its first use?
No, the Osphena Savings Card does not need to be activated before you use it.
Must I wait a specific number of days between prescription fills to get my next refill and use the savings offer?
The Osphena Savings Card does not require that patients wait a specific number of days between prescription refills; however, your individual insurer may limit how quickly they will approve your monthly refill. It is recommended that you check with your insurance provider for details.
Can I use the Osphena Savings Card for purchases from a mail-order pharmacy?
Yes. The Osphena Savings Card may be used with mail-order purchases with a valid prescription. To redeem the offer, simply provide your mail-order pharmacy with the Osphena Savings Card information.
What if I misplace or damage my Osphena Savings Card?
If you misplace or damage your Osphena Savings Card, you can download a new one. Your pharmacy may also keep a record of your Osphena Savings Card on file.
Do I need to show the Osphena Savings Card to the pharmacist each time I need a refill?
Although some pharmacies may keep your Osphena Savings Card information on file, it’s best to always bring your Osphena Savings Card to the pharmacy with your valid Osphena® prescription or refill request.
Can I use more than one Osphena Savings Card at the same time?
No, you can only use one Osphena Savings Card at a time. Your Osphena Savings Card is valid for several uses. You don't need to use a different card each time. Your pharmacy may also keep a record of your Osphena Savings Card on file so that you don't have to show your card each time.
Can I use the Osphena Savings Card if I have not met my deductible?
Yes. Your out-of-pocket expense can be applied to your deductible.
If I have an Osphena Savings Card, do I still need a prescription?
Yes. The Osphena Savings Card is for use ONLY with a valid Osphena® prescription.
Is the Osphena Savings Card accepted at all pharmacies?
The Osphena Savings Card is accepted at most retail pharmacies in the United States and Puerto Rico. If a pharmacy decides not to accept the offer, you may receive savings by requesting a rebate check after you have purchased your Osphena® prescription. Simply call the number on the back of your Osphena Savings Card for information on how to submit a request for reimbursement.
Is there a patient assistance program for patients who cannot afford Osphena?
Duchesnay USA does not offer a patient assistance program at this time.
If I previously used a savings offer, am I eligible to use the new savings offer?
Yes. Even if you have previously used an Osphena Savings Card, you may present a valid prescription at the pharmacy with your new savings card and you will be eligible for the new offer.

Want to speak to an Osphena® representative?

Call 1-855-OSPHENA

Monday to Friday
8:30 am to 5:30 pm EST



If you’re looking for additional information about Osphena®, click below to view our Frequently Asked Questions.

Get Answers to Questions About Osphena®



Duchesnay USA offers great savings programs that may make this treatment option affordable.

Save on Your Osphena® Prescription

For U.S. Residents Only