Important Safety Information Including Boxed Warning and Indication

Most Important Information you should know about Osphena®

Osphena® works like estrogen in the lining of the uterus, but can work differently in other parts of the body. Taking estrogen alone or Osphena® may increase your chance for getting cancer of the lining of the uterus. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause, so tell him or her right away if this happens while you are using Osphena®.

Osphena® may increase your chances of having a stroke or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena®.

Call your healthcare provider right away if you have changes in vision or speech, sudden new severe headaches, and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue. Osphena® should not be used if you have unusual vaginal bleeding, have or have had certain types of cancers (including cancer of the breast or uterus), have or have had blood clots, have had a stroke or heart attack, have severe liver problems, are allergic to Osphena® or any of its ingredients, or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.

Possible side effects of Osphena®

Serious but less common side effects can include stroke, blood clots and cancer of the lining of the uterus.

Common side effects may include hot flashes, vaginal discharge, muscle spasms and increased sweating.

Tell your healthcare provider about all of the medicines and supplements you take, as some medicines may affect how Osphena® works. Osphena® may also affect how other medicines work.

Duchesnay USA encourages you to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Indication: What is Osphena®?

Osphena® is a prescription oral pill that treats moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Please read accompanying Patient Information for Osphena®(ospemifene) tablets, including Boxed Warning in the U.S. Full Prescribing Information.

For U.S. Residents Only
Osphena® Savings

Save on Osphena®

Filling your prescription for Osphena® is the first step in getting relief from your moderate to severe painful sex due to menopause.

The Osphena® Savings Program offers 2 great ways to save on your 30- or 90- day prescription  

Get your prescription at your local retail pharmacy or have it delivered directly to your home.

The Osphena®  Savings Card

OPTION 1 - Traditional Retail Pharmacy

Commercially covered patients

Pay as
little as
for 30 or 90

Download Savings Card

Patient instructions

  • Click on the Savings Card button above and print your personalized savings card.
  • Present this offer to your pharmacist along with a valid prescription for Osphena® (ospemifene).

If you have any questions about the Osphena® Savings Card, please call 1-866-339-0316

Cash-paying patients and commercially insured patients who are not covered for Osphena® pay as little as $75 for 30 tablets or $200 for 90 tablets.

Osphena At Home®

OPTION 2 - Mail Order Pharmacy

Commercially covered patients

Pay as
little as
for 30 or 90

Cash-paying patients and commercially insured patients who are not covered for Osphena® pay as little as $40 for 30 tablets or $80 for 90 tablets.

Healthcare professional:
Prescribe Osphena® by calling, faxing or ePrescribing through ProCare Pharmacy Care Osphena At Home® program’s (FREE SHIPPING).

  • On-staff pharmacists to answer product questions
  • Assistance with payer benefit verification and copay savings information
  • Assistance with monthly refills

Have questions? Call 1-844-716-HOME (4663) from Monday to Friday 8:00 am to 11:00 pm EST.

Learn More

Want to speak to an Osphena® representative?

Call 1-855-OSPHENA

Monday to Friday
8:30 am to 5:30 pm EST



If you’re looking for additional information about Osphena®, click below to view our Frequently Asked Questions.

Get Answers to Questions About Osphena®



Duchesnay USA offers great savings programs that may make this treatment option affordable.

Save on Your Osphena® Prescription

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