Important Safety Information Including Boxed Warning and Indication


Osphena® works like estrogen in the lining of the uterus (endometrium), but can work differently in other parts of the body. Taking estrogen alone or Osphena® may increase your chance for getting cancer of the lining of the uterus. Vaginal bleeding after menopause may be a warning sign of cancer of the lining of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause, so tell him or her right away if this happens while you are using Osphena®.

Osphena® may increase your chances of having a stroke or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with Osphena®.

Indication: What is Osphena®?

Osphena® is a prescription oral pill that treats:

  • moderate to severe painful intercourse,
  • moderate to severe vaginal dryness, symptoms of changes in and around your vagina, due to menopause.

Most Important Information you should know about Osphena®

Call your healthcare provider right away if you have unusual vaginal bleeding, changes in vision or speech, sudden new severe headaches, and pains in your chest or legs with or without shortness of breath, weakness and fatigue.

Who should not take OSPHENA?

Osphena® should not be used if you have unusual vaginal bleeding, have or have had certain types of cancers (including cancer of the breast or uterus), have or have had blood clots, had a stroke or heart attack, have severe liver problems, are allergic to Osphena® or any of its ingredients, or think you may be pregnant. Tell your healthcare provider if you are going to have surgery or will be on bed rest.


Serious but less common side effects can include:

  • stroke
  • blood clots
  • cancer of the lining of the uterus

Less serious, but common side effects include:

  • hot flushes or flashes
  • vaginal discharge
  • muscle spasms
  • headache
  • excessive sweating (hyperhidrosis)
  • heavy vaginal bleeding (vaginal hemorrhage)
  • night sweats

Tell your healthcare provider about all of the medicines and supplements you take, as some medicines may affect how Osphena® works. Osphena® may also affect how other medicines work.

Duchesnay USA encourages you to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please read accompanying Patient Information for Osphena®(ospemifene) tablets, including Boxed Warning in the U.S. Full Prescribing Information.

Osphena® now also indicated for moderate to severe vaginal dryness, a symptom of changes in and around your vagina due to menopause
Osphena® Savings

Save through Osphena® Savings Programs

If you have commercial insurance, there are two easy ways to pay as little as $0 for your Osphena® prescription.

Savings options also available for those who do not have prescription insurance or whose insurance does not cover Osphena®.

Learn more about Osphena® savings options

Option 1: If you wish to fill your prescription at a local retail pharmacy.

Simply present your eligible Osphena® prescription and an Osphena® CoPay Savings Card to your pharmacist.

Download Savings Card

If you do not have prescription insurance or your insurance does not cover Osphena®, you could pay only $75 for 30 tablets or $190 for 90 tablets.

Option 2: If you wish to fill your prescription through a mail order pharmacy.

Ask your healthcare professional to prescribe through the Osphena At Home® program. In addition to saving on your prescription, the program also offers the convenience of free home delivery, on-staff pharmacists to answer your product questions, assistance with insurance benefit verification and monthly refill reminders.

Download Osphena At Home® Patient Instructions

Cash-paying patients, Medicare patients that elect to pay cash and commercially insured patients who are not covered for Osphena® pay only $40 for 30 tablets or $80 for 90 tablets.

Your healthcare provider can send your prescription directly to ProCare Pharmacy Care. Once your prescription has been submitted, you will receive a call within 24 hours from ProCare Pharmacy Care (844 area code) OR you can call them directly at 844-716-4663 .

Want to speak to an Osphena® representative?

Call 1-855-OSPHENA

Monday to Friday
8:30 am to 5:30 pm EST



If you’re looking for additional information about Osphena®, click below to view our Frequently Asked Questions.

Get Answers to Questions About Osphena®



Duchesnay USA offers great savings programs that may make this treatment option affordable.

Save on Your Osphena® Prescription

For U.S. Residents Only